I. Developing Mechanically-Tuned 3D Biomaterial Systems for Cells
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IMPORTANCE
In native tissues, cells continuously respond to dynamic mechanical signals from their microenvironment, and alternation of these cues is linked to diseases like fibrosis, cancer, and impaired regeneration. Thus, precise control of biomaterial mechanics is essential for building physiologically relevant models and designing effective therapies.
Mechanical Cues in the Cellular Niche
Engineering 3D Matrices for Mechanical Property Control
APPROACH
We develop engineered 3D systems with programmable mechanical properties to actively control cell behavior and guide tissue-level responses. By integrating tunable hydrogel matrices and microstructured scaffolds, we deliver spatially and temporally defined physical cues.
These platforms enable mechanically regulated modulation of cell fate, offering a powerful toolset for steering stem cell function, redirecting pathological remodeling, and reprogramming disease-associated phenotypes. Crucially, they function as dynamic biointerfaces that support mechanosensitive molecular screening, driving the development of future therapeutics.
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